J Venom Res (2021), Vol 11, 26-33
Published online: 28 May 2021
Full Text (D’Amelio ~1196kb)
Fernanda D’Amélio1, 2*, Hugo Vigerelli1,2,3, Álvaro Rossan de Brandão Prieto da Silva1 and Irina Kerkis1,3*
1Laboratory of Genetics, Butantan Institute, São Paulo, SP, Brazil
2The Postgraduate Program in Toxinology, Butantan Institute, São Paulo, SP, Brazil
3Centre of Excellence in New Target Discovery (CENTD), Butantan Institute, São Paulo, SP, Brazil
Received: 19 May 2021 | Revised: 28 May 2021 | Accepted: 28 May 2021
© Copyright The Author(s). This is an open access article, published under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction of this article, provided the original work is appropriately acknowledged, with correct citation details.
Belonging to the Viperidae family, Bothrops moojeni are widely distributed in South America, tropical savanna ecoregion (Cerrado) of Argentina, Bolivia, Brazil, and Paraguay with medical importance in Brazil. Accidents caused by this species have a rapid local action with the development of tissue inflammation, causing erythema, pain, and increased clotting time, which can culminate in gangrene or tissue necrosis. Bothrops moojeni venom has a rich composition that remains underexplored, which is of utmost importance, both for elucidating the envenoming process and the vast library of new bioactive molecules kind of venom can offer. This review aims to analyze which components of the venom have already been characterized towards its structure and biological effect and highlight the pharmacological and biotechnological potential of this venom. Although snake venoms have been studied for their toxic effects for generations, innovative studies address their components as tools for discovering new therapeutic targets and new molecules with pharmacological and biotechnological potential.
KEYWORDS: Bothrops moojeni, components, Snake venom, metalloprotease, serinoprotease, phospholipase, L-amine oxidase acid.